FunGO

Decoding Protein Function from Sequence

FunGO is designed to infer protein function directly from amino acid sequences. It predicts Gene Ontology (GO) annotations across Molecular Function, Biological Process and Cellular Component, providing a comprehensive functional profile of proteins.

1Paste FASTA sequence
→
2Run prediction
→
3Explore GO annotations

Sequence Input

FASTA format · max 10 sequences

No sequences

Ctrl+Enter to submit

Evidence Tiers

Score = IA weight × confidence · Tier reflects GO term specificity

Strong Evidence

IA > 3.0 · conf ≥ 0.20

Highly specific GO term — even moderate confidence is meaningful

Moderate Evidence

IA > 1.0 · conf ≥ 0.30

Moderately specific term with acceptable model confidence

Indicative

IA > 0.03 · conf ≥ 0.40

Lower specificity — high confidence required to qualify

Paste a FASTA sequence to begin

Predictions are returned across all three GO ontologies, ranked by combined specificity and confidence score.

Molecular FunctionBiological ProcessCellular Component